3 weeks ago
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Chimeric antigen receptor (CAR) T-cell therapy, an attack that modifies a patient’s ain immune cells to hunt down cancer, has transformed attraction for humor cancers specified arsenic leukaemia and lymphoma. But the aforesaid strategy has struggled erstwhile applied to coagulated tumours specified arsenic kidney oregon ovarian cancer.
One of the biggest obstacles is antigen heterogeneity. Tumours are not made of identical cells. Instead, they lucifer a patchwork: immoderate cells show the macromolecule that CAR-T cells observe portion others look to deficiency it. CAR-T cells lone destruct ‘visible’ targets, truthful the invisible cells past and let the crab to turn back.
Now, a survey published successful Science connected February 26 has suggested these supposedly invisible cells whitethorn not beryllium invisible aft all. Many tumour cells thought to deficiency the people macromolecule really transportation tiny amounts — excessively small for existent CAR-T cells to detect.
