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An Andhra University probe squad moving nether the guidance of Ravikiran Yedi, laminitis of TCABS-E Laboratories incubating astatine the university, connected Sunday (November 23) announced that it has discovered a caller mechanics by which the coronavirus evades COVID-19 vaccines.
According to their probe conducted during the Covid-19 pandemic, the spike macromolecule of the microorganism has an ‘escape mechanism’ from the antibodies produced by the vaccines, they said.
Speaking to The Hindu on Sunday, Mr. Ravikiran Yedidi said the viral spike macromolecule constituent exhibits a modulation betwixt coagulated and liquid states erstwhile it fights with the antibodies generated by the vaccines. This flight mechanism’ confuses the antibodies. While antibodies are designed to combat the coagulated authorities of the spike macromolecule of the Corona virus, they cannot combat the spike macromolecule successful the liquid state. This is wherefore antibodies did not enactment connected immoderate patients during the pandemic period.
Their squad has been moving connected this since 2022 and yet succeeded successful publishing this find successful Elsevier journal connected November 19, 2025. The work discusses the results based connected molecular biology, biotechnology, biochemical and biophysical analysis, helium added.
Additionally, machine simulations were besides performed to enactment the laboratory findings. With this robust experimental investigation the squad is assured that this signifier modulation volition not lone pb to reduced vaccine efficacy but besides volition make much variants of coronavirus successful future, helium added.
Speaking astir the solutions to this problem, Ravikiran Yedidi said: “We person discovered a problem. Now, we are going to invent a solution. We mightiness request assistance from AI and Quantum Computing technologies successful operation with biotechnology successful bid to travel up with a plausible solution that tin alteration the full tract of vaccine design.”
AU Vice-Chancellor G.P. Raja Sekhar portion congratulating the squad for deciphering this caller mechanics of vaccine-resistance, advised them to spell heavy into the research.
